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ACUTE EXPOSURE INFORMATION

1. Terephthalic Acid is a mild respiratory tract and eye irritant. In experimental animals, it is mildly toxic by the intraperitoneal and intravenous routes.
   1. In general, phthalate compounds are of a low order of toxicity among chemicals used in industrial settings. They are not appreciably absorbed by the dermal or inhalation routes.

2. Terephthalic acid causes aciduria, elevated calcium and magnesium excretion, and slightly elevated serum magnesium and calcium levels in rats.
   1. Terephthalic acid induced urinary bladder calculi and urinary system transitional cell hyperplasia in experimental animals.
   2. In dogs, sublethal terephthalic acid injection caused a decrease in aortic blood pressure.
   3. In rats chronically exposed to terephthalic acid, a decreased uptake of norepinephrine by grey matter snyaptosomes and activation of catechol-O-methyl-transferase and monoamine oxidase in the cerebral hemispheres has been noted.

3. When heated to decomposition, terephthalic acid may release irritating fumes and acrid smoke which might cause respiratory tract irritation if inhaled.

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