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ACUTE EXPOSURE INFORMATION

  1. USES: A triazole derivative used to treat seizures associated with Lennox-Gastaut syndrome in adults and in children 4 years of age and older.
  1. PHARMACOLOGY: The exact mechanism of action is unknown. In vitro studies suggest that rufinamide modulates the activity of sodium channels and subsequently prolongs the inactive state of the channel.
  1. EPIDEMIOLOGY: Overdose is very rare.
  1. WITH THERAPEUTIC USE
    1. ADVERSE EFFECTS: COMMON: Somnolence, nausea, vomiting, headache, fatigue, and dizziness. Other adverse effects that may occur: decreased appetite, rash, pruritus, ataxia, diplopia, blurred vision, abdominal pain, multiorgan hypersensitivity syndrome, shortening of the QT interval, and suicidal thinking or behavior.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Overdose information is limited. An adult received an overdose of 7200 mg/day of rufinamide during the clinical trials and did not experience any major adverse effects.
    1. SEVERE TOXICITY: Based on limited data, none reported.
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