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ACUTE EXPOSURE INFORMATION

1. Cyclonite does NOT have nitrate-like toxicity. It may be toxic by inhalation, ingestion, or skin and eye exposure.

2. Cyclonite is a corrosive irritant of the eyes, skin, mucous membranes and respiratory tract, but it mainly affects the central nervous system, acting as a depressant.

3. Exposure may result in dermatitis, mucous membrane ulceration, salivation, anorexia, nausea, vomiting, hematuria and renal tubular damage. Neurologic symptoms may include weakness, asthenia, dizziness, headache, insomnia, irritability, stupor, unconsciousness and seizures.

4. Prominent signs and symptoms after ingestion have included staring into space, generalized seizures, lethargy, coma, muscular twitching, hyperreflexia, myalgias, headaches, vomiting, mild renal injury and hematuria.
   1. Additional effects following oral exposure have included: methemoglobinemia, metabolic acidosis with anion gap, hypokalemia, hyperglycemia, and increased liver enzymes. Onset is typically delayed for 3 to 12 hours after ingestion. Gastrointestinal effects are usually noted by 3 hours after ingestion, and central nervous system effects, 8 to 12 hours after ingestion.

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