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Example Content from MEDITEXT for 148553-50-8:


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ACUTE EXPOSURE INFORMATION

  1. USES: Pregabalin is indicated for the treatment of diabetic or postherpetic neuralgia, fibromyalgia, and partial seizures.
  1. PHARMACOLOGY: The mechanism of action in humans is unknown; however, pregabalin possibly modulates calcium channel function by reducing the calcium-dependent release of several neurotransmitters in vitro and binds with high affinity to the alpha(2)-delta site in central nervous system tissues, which may lead to antiseizure and antinociceptive effects.
  1. EPIDEMIOLOGY: Overdose is rare.
  1. WITH THERAPEUTIC USE
    1. ADVERSE EFFECTS: COMMON: dizziness and somnolence, ataxia, tremor, amnesia, speech disturbances, myoclonus, neuropathy, confusion, euphoria, incoordination, abnormal gait, nervousness, twitching, headache. LESS COMMON: peripheral edema, a mildly prolonged PR interval, decreased platelet count, and increased creatine kinase, rhabdomyolysis and blurred vision.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Overdose data are limited. During clinical trials, the highest reported accidental overdose of pregabalin was 8000 mg; no notable consequences were observed. During clinical studies, some patients took as much as 2400 mg/day. Adverse events in patients exposed to doses greater than or equal to 900 mg were not clinically different from those of patients who received recommended doses of pregabalin.
    1. SEVERE TOXICITY: An adult intentionally ingested 8.4 g of pregabalin and developed CNS depression and coma approximately 3 hours after exposure. The patient required intubation and mechanical ventilation for 26 hours. No permanent sequelae occurred.
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