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ACUTE EXPOSURE INFORMATION
- Bromadiolone is a derivative of 4-hydroxycoumarin. In massive overdose, these agents have produced rapid and persistent hypoprothrombinemia and associated bleeding diathesis. Once coagulation defects occur, they may persist for weeks to months. Daily exposures are likely to produce cumulative toxicity. No chronic data were found for bromadiolone in humans, however. This review is based on the properties of coumarin and other long-acting anticoagulants.
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