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• A case of lithium-induced cardiovascular malformations.
• A prospective, multicentre study of pregnancy outcome following first trimester exposure to fluoxetine (ProzacÑ).
• A prospective, multicentre study of pregnancy outcome following first trimester exposure to fluoxetine.
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Example Content from MEDITEXT for 54910-89-3:


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ACUTE EXPOSURE INFORMATION

  1. USES: Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) and is used for depressive disorder, obsessive-compulsive disorder, panic attack, and bulimia nervosa.
  1. PHARMACOLOGY: Fluoxetine and its active metabolite norfluoxetine inhibit reuptake of serotonin from the synaptic cleft, therefore increasing serotonergic neurotransmission.
  1. TOXICOLOGY: Severe toxicity is not common, but may develop from excessive serotonergic effects, particularly when fluoxetine is ingested with another agent that increases CNS serotonin.
  1. EPIDEMIOLOGY: Poisoning with fluoxetine and other SSRIs are common. Life threatening toxicity is rare, and patients usually recover without sequelae.
  1. WITH THERAPEUTIC USE
    1. ADVERSE EFFECTS: Somnolence, dizziness, insomnia, nervousness, headache, nausea, vomiting, and diarrhea are often reported. Hyponatremia, due to inappropriate secretion of antidiuretic hormone (SIADH), may be observed.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE POISONING: Somnolence, dizziness, nausea, and vomiting are common; QTc prolongation may occur even in therapeutic or mild overdose.
    1. SEVERE POISONING: Significant CNS depression, seizures, and QTc prolongation. Ventricular dysrhythmias have rarely been reported. Serotonin toxicity (autonomic instability, altered mental status, seizures, muscle rigidity, hyperreflexia, and hyperthermia) may occur; however, most reported cases involve patients using multiple serotonergic agents.
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