RightAnswer Knowledge Solutions Search Results for 58-08-2

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• CAFFEINE

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• CAFFEINE

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• CAFFEINE

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• CAFFEINE

DART Documents

• [Analysis of drugs in maternal and neonatal hair for the evaluation of BRON solution and methamphetamine use during pregnancy]
• [Application of the Chinese hamster V79 cell metabolic cooperation assay for screening teratogens and its reliability]
• [Coffee and pregnancy]

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• [Effects of caffeine on the growth of embryos in lymnaeid snails]
• [Potentiating effects of caffeine on the 5-fluoro-2'-deoxyuridine or mitomycin C induced mutagenesis and teratogenesis in pregnant mice]
• A new in vitro screening method for teratogens using human embryonic palatal mesenchymal cells.
• A prospective study of caffeine consumption and spontaneous abortion.
• A retrospective appraisal of the ability of animal tests to predict reproductive and developmental toxicity in humans.
• Acute maternal and fetal cardiovascular effects of caffeine ingestion.
• An assessment of reproductive and developmental effects of caffeine in animals.
• An interlaboratory evaluation of five pairs of teratogens and non-teratogens in post-implantation rat embryo culture.
• Antenatal visualization of malformations associated with drugs and chemicals.
• Appearance of tetraploidy cells in rat hindlimb buds treated with 5-azacytidine.
• Application of fluorescence microscopy to investigation of abnormal development of limb buds in mouse embryos: in vivo and in vitro.
• Association of caffeine consumption during pregnancy and spontaneous abortion.
• Caffeine - a human teratogen?
• Caffeine ameliorates cadmium sulfate-induced forelimb ectrodactyly in C57BL/6J mice.
• Caffeine and nicotine: effects on human placental vascular tone in vitro.
• Caffeine as a tool for manipulating cell calcium: chronic versus pulsed application in mitotic sea urchin eggs.
• Caffeine consumption during pregnancy: effects on spontaneous abortion and intrauterine growth.
• CAFFEINE ENHANCES THE EMBRYOTOXICITY OF ANTIEPILEPTIC DRUGS IN RAT POSTIMPLANTATION WHOLE EMBRYO CULTURE.
• Caffeine increases the embryotoxicity of cyclooxygenase inhibitors - summary of the first generation study in rat.
• Caffeine intake during pregnancy and the risk of intrauterine growth retardation and preterm birth.
• Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell culture and rat placenta.
• Caffeine treatment does not alter cerebral lactate levels in premature newborns with apnea.
• Cardiovascular malformations induced by caffeine in chick embryos.
• Cardiovascular responsiveness to adenosine agonists is different in lambs exposed prenatally to caffeine.
• Cell death prevents congenital malformations in mice.
• Cerebral amino acids in neonate from caffeine-drinking dam.
• Chick embryo limb bud cell culture for screening environmental contaminants.
• Chick embryo limb bud cultures as potential screens for skeletal toxicants.
• Chromosome fragile sites in aging.
• Cigarettes, coffee, and preterm premature rupture of the membranes.
• Combined effects of caffeine and zinc in the maternal diet on fetal brains.
• Combined effects of radiation and caffeine on cleft palate and abnormalities of extremities.
• Combined effects of radiation and caffeine on embryonic development in mice.
• Combined effects of radiation and caffeine on embryonic development of mice aged on day 7 of gestation.
• Comparison of two diagnostic criteria of trophism at birth with regard to maternal risk factors identified early in pregnancy.
• Correlations of various pharmacokinetic parameters with endpoints in teratogenicity testing.
• Craniofacial ossification in the rat following in utero exposure to alcohol and caffeine.
• Cytotoxicity test using blastocyst-derived euploid embryonal stem cells: a new approach to in vitro teratogenesis screening.
• Danio rerio embryotoxicity and teratogenicity assay (DRETA) for detecting waterborne embryo-toxicants and teratogens.
• Development of monooxygenase activity and the induction by 2,3,7,8-TCDD in rats and marmosets measured with the 14C-caffeine CO2-breath-test.
• Do antiepileptic drugs combined with caffeine increase the risk of birth defects?
• Does caffeine increase embryotoxicity of paracetamol and propyphenazone?
• Dose-response relationships in caffeine-mediated potentiation of acetazolamide teratogenicity among C57 black mice.
• Drosophila melanogaster embryo cultures: an in vitro teratogen assay.
• Drug induced infertility.
• Drug therapy in pregnancy and lactation.
• EFFECT OF CAFFEINE AND ADP ON IN VITRO FERTILIZATION OF PORCINE OOCYTES.
• Effect of caffeine on fetal heart rate pattern.
• Effect of caffeine on saturated and monounsaturated free fatty acids of the newborn rat heart.
• Effect of caffeine on the saturated and monounsaturated free fatty acids of the newborn rat cerebellum.
• Effect of in utero caffeine exposure on discrimination reversal performance in infant monkeys.
• Effect of in utero caffeine exposure on spatial and non-spatial matching to sample performance in infant monkeys.
• Effects of caffeine and related methylxanthines on fetal mouse palates cultured in vitro.
• Effects of caffeine on osteoblasts derived from fetal rat calvaria.
• Effects of caffeine on ovine maternal glucose-insulin response and fetal metabolite levels.
• Effects of caffeine on the developmental potential of in vitro matured, aged and denuded ovine oocytes.
• Effects of caffeine on the myoblasts of Xenopus larvae.
• Effects of chronic pre- and postnatal chlordane exposure, food deprivation and caffeine on neurobehavioral indices in the rat.
• Effects of heavy metals on chondrogenic differentiation of embryonic chick limb cells.
• Effects of in utero exposure to alcohol plus caffeine in rats. I. Pregnancy outcome and early offspring development.
• Effects of in utero exposure to alcohol plus caffeine in rats. II. Behavioral teratology.
• Effects of maternal ingestion of caffeine during pregnancy on the offspring.
• Effects of moderate prenatal alcohol exposure on teacher-rated classroom behavior and academic performance in children aged 11 years.
• Effects on elevated plus-maze behavior of exposure to caffeine during both gestation and lactation.
• Establishment of an organ culture system for fetal rat palates and its validation for detection of teratogenicity.
• Ethanol and caffeine negatively impact growth in a chicken embryo but caffeine alone does not impact viability.
• Evaluation of a fish embryo-larval development assay using six compounds recommended for in vitro teratogenesis test validation.
• Evaluation of cartilage findings in fetuses from control and caffeine-treated rats.
• Evaluation of the relative teratogenic potencies of caffeine and caffeine metabolites using FETAX.
• Evaluation of the V79 cell metabolic co-operation assay as a screen in vitro for developmental toxicants.
• Fetal and neonatal respiratory activity and its modulation by adenosine and caffeine.
• FETAX interlaboratory validation study: phase II testing.
• Final report on the reproductive toxicity of caffeine (CAS no. 58-08-2) administered by gavage to Sprague-Dawley rats.
• Fish embryotoxicity and teratogenicity of pharmaceuticals, detergents and pesticides regularly detected in sewage treatment plant effluents and surface waters.
• Frog embryo teratogenesis assay-Xenopus: a nonmammalian method for developmental toxicity assessment.
• Further development and validation of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX), phase III.
• Further development and validation of the Frog Embryo Teratogenesis Assay-Xenopus (FETAX).
• Further evaluation of a teratogenicity screen using an intravitelline injection technique.
• Heat shock protein synthesis is not part of caffeine's mechanism of action.
• In vitro micromass teratogen test: interpretation of results from a blind trial of 25 compounds using three separate criteria.
• In vitro micromass teratogen test: results from a blind trial of 25 compounds.
• In vitro teratogenicity studies of caffeine.
• Induction of low-molecular-weight heat-shock proteins in Drosophila and human embryonic lineage cells after teratogen exposure.
• Influence of acetaminophen, isopropylantipyrine and caffeine on the liver of pregnant and non-pregnant animals in morphological and biochemical studies.
• Influence of caffeine on the mRNA expression of type III iodothyronine deiodinase and thyroid hormone receptor in BeWo cell culture and rat placenta.
• Influence of caffeine on the teratogenicity of cocaine in CF-1 mice.
• Influence of prenatal exposure to combination of acetaminophen, isopropylantipyrine and caffeine on embryonic development.
• Interactive effects of ethanol and caffeine on rat fetal hepatocyte replication and EGF receptor expression.
• Interlaboratory evaluation of the Frog Embryo Teratogenesis Assay -- Xenopus (FETAX): part II.
• Interspecies comparison of A/D ratios: mouse.
• Interspecies comparison of A/D ratios: Xenopus.
• Intravitelline injection of rodent conceptuses: an improved in vitro developmental toxicity screen.
• Legal recreational drugs: alcohol, smoking and caffeine.
• Long-term impact of neonatal caffeine on sleep architecture in freely-behaving adult rats.
• Malformation of the joints and bones induced by caffeine in the mouse fetuses.
• Maternal and fetal cardiovascular effects of acute caffeine ingestion.
• Maternal caffeine consumption and umbilical artery velocimetry in normal third trimester pregnancy.
• Maternal caffeine intake and intrauterine growth retardation.
• Maternal serum caffeine and paraxanthine levels and third trimester fetal biophysical activity.
• Maternal-fetal electrocardiographic effects and pharmacokinetics after an acute iv administration of caffeine to the pregnant rat.
• Modifying factors in prenatal carcinogenesis (review).
• Modulation of methotrexate-induced cytogenotoxicity in mouse spermatogonia and its transmission in the male germline by caffeine.
• Morphological studies on the effects of caffeine on Xenopus laevis larvae.
• Mother's caffeine intake in pregnancy and risk factors of SIDs.
• Neurological disease and epilepsy.
• Optimizing the experimental design of the FETAX assay.
• Placental transfer of drugs and fetal risks.
• Pre- and postnatal induction of monooxygenases by 2,3,7,8-TCDD in rats and monkeys measured with the 14C-caffeine CO2-breath-test.
• Preconception care.
• Preconceptual caffeine exposure affects pre- and postnatal development.
• Preconceptual caffeine exposure increases glucose utilization and accelerates development in the preimplantation rat embryo.
• Pregnancy and fetal outcome following maternal exposure to alcohol and caffeine in the rat.
• Prenatal alcohol exposure and reduced gestational age in offspring of teenagers.
• Prenatal alcohol exposure and young adult drinking: a 21-year longitudinal analysis.
• Prenatal submucosal administration of caffeine tablets affects molar enamel structure.
• Prevalidation of the embryonic stem cell test (EST)--a new in vitro embryotoxicity test.
• Regular Coffee Intake is Related to Increased Sperm Motility and Antioxidant Levels in Infertile Men.
• Relation between reported maternal caffeine consumption during pregnancy and neonatal state and heart rate.
• Reproductive effects of caffeine in S-D rats assessed by the continuous breeding protocol.
• Risk factors for early pregnancy loss.
• Role of facial hematomas in, and the interaction of DMSO with, caffeine-induced cleft palate in mice.
• Significance of the minor alterations of the axial skeleton in rat foetuses: A short review.
• Smoking, caffeine, preterm delivery, and PROM.
• Statistical analysis of combined effects of two agents on embryonic development in mice.
• Study on the identification of fetal caffeine syndrome.
• Subclinical and clinical pregnancy loss: incidence and risk factors in a cohort of working women.
• Synergistic effect of caffeine and cadmium chloride in induction of cleft palate in mice.
• Systematic review: Caffeine intake and spontaneous abortion.
• Teratogenic drugs inhibit the differentiation of fetal rat limb buds grafted in athymic (nude) mice.
• Teratogenic Potential of Citrus aurantium.
• Teratopharmacological and behavioural effects of coffee in mice.
• The cause and prevention of human birth defects: what have we learned in the past 50 years?
• The effect of caffeine and smoking on the prevalence of Down syndrome.
• The effect of caffeine on rat embryo's osteogenesis.
• The effects of adenosine or phenylisopropyladenosine on the teratogenicity of caffeine in the embryonic chick heart.
• The effects of in utero exposure to caffeine on infant monkeys.
• The effects of prenatal administration of vasopressin, oxytocin, and caffeine on 25-day retention of a passive-avoidance response in adult rats.
• The embryonic stem cell test, an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells.
• The interpretation of results from teratology and reproductive toxicity tests including comments on the new draft guidelines.
• The relative semi-quantification of mRNA expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances.
• The stem-cell test -- a novel in vitro assay for teratogenic potential.
• The stem-cell test: an in vitro assay for teratogenic potential. Results of a blind trial with 25 compounds.
• Three in vitro toxicity/teratogenicity test systems validated by using twelve identical coded compounds.
• Toxicological approach for predicting embryotoxicity using mouse embryonic stem cells.
• Tryptophan hydroxylase activity is increased by forskolin or phosphodiesterase inhibitors in cultures from fetal rat brainstem.
• Using genetic expression profiling to determine potential reproductive toxicity and carcinogenicity.
• Validation of three in vitro toxicity/teratogenicity test systems using identical coded compounds. I. Aggregating brain cell cultures.
• Validation of three in vitro toxicity/teratogenicity test systems using identical coded compounds. II. Standardized in vitro culture of the whole chick embryo.
• Validation of three in vitro toxicity/teratogenicity test systems using identical coded compounds. III. The post-implantation rat embryo culture.
• Validation of whole chick embryo cultures, whole rat embryo cultures and aggregating embryonic brain cell cultures using six pairs of coded compounds.
• What can be done about intrauterine growth retardation?

ECOTOX Documents

• 3,7-Dihydro-1,3,7-trimethyl-1H-pyrine-2,6-dione

Fisher MSDS

• 4-(4-chlorophenyl)piperidin-4-ol
• Caffeine
• Caffeine

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• Caffeine (in French)
• Caffeine (in French)
• CAFFEINE (in French)
• Caffeine, 1mg/ml in methanol
• Caffeine, 1mg/ml in methanol (in French)

GENE-TOX Documents

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• CAFFEINE

LOLI® Listings

• Caffeine ( 58-08-2)
• Caffeine ( 71701-02-5)
• Caffeine ( 95789-13-2)

NTP - Reproductive Toxicology Study Abstracts

• Caffeine (CAS #58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
• Caffeine (CAS #58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
• Reproductive Toxicity of Caffeine (CAS #58-08-2) Administered by Gavage to Sprague-Dawley Rats

REPROTOX® Documents

• CAFFEINE

RTECS® Registry

• Caffeine

Shepard's Catalog

• Caffeine

TERIS Documents

• CAFFEINE

MSDSonline®

(429) English MSDSs - (click to search other languages)

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Example Content from MEDITEXT for 58-08-2:

ACUTE EXPOSURE INFORMATION

1. USES: Caffeine (1,3,7-trimethylxanthine) is present in coffee, tea, colas, and chocolate. It is also utilized in over-the-counter cough and cold therapies, and in many dietary supplement products used as anorexiants, diuretics, and stimulants. Botanical sources of caffeine include: guarana, yerba mate, and kola nuts. Caffeine is used medicinally for neonatal apnea and postlumbar puncture headache.

2. PHARMACOLOGY: Caffeine is a trimethylxanthine closely related to theophylline. It acts through nonselective inhibition of adenosine receptors and phosphodiesterase. There is also beta-1 and beta-2 adrenergic stimulation secondary to catecholamine release.

3. TOXICOLOGY: Caffeine is an adenosine analog and functions primarily as an adenosine antagonist lowering the seizure threshold. It also inhibits phosphodiesterase, resulting in accumulation of cAMP and calcium, causing organ-specific downstream effects such as smooth muscle relaxation, or muscle/cardiac/CNS excitation. Caffeine overdoses result in surges in circulating catecholamines and rennin, as well as increased levels of norepinephrine, dopamine, and serotonin in the brain.

4. EPIDEMIOLOGY: Caffeine is commonly used; however, severe manifestations of toxicity are rare, and most exposures result in mild toxicity.

5. WITH POISONING/EXPOSURE
   1. MILD TO MODERATE TOXICITY: The earliest symptoms of acute caffeine poisoning include: anorexia, tremor, and restlessness, followed by nausea, vomiting and tachycardia. Chronic high-dose caffeine intake can lead to "caffeinism" which includes nervousness, twitching, anxiety, tremulousness, insomnia, palpitations, and hyperreflexia.
   2. SEVERE TOXICITY: With serious ingestions hypokalemia, hyperglycemia, metabolic acidosis, rhabdomyolysis, hypotension, confusion, seizures, tachycardia, and nonfatal dysrhythmias may occur.