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ACUTE EXPOSURE INFORMATION

  1. Very little information is available about cyanuric fluoride and its potential toxicity. The material readily penetrates through the skin, and is quite irritating. At the time of this review, NO DATA INDICATING THAT CYANIDE POISONING CAN OCCUR FOLLOWING EXPOSURE were found.
    1. Should an exposed patient exhibit signs or symptoms of CYANIDE POISONING, REFER to the POTASSIUM CYANIDE management for evaluation and treatment recommendations.
  1. Most of the clinical effects and treatment recommendations below are derived from information regarding the similar chlorinated derivative, CYANURIC CHLORIDE, classified as a moderately toxic substance.
    1. Respiratory tract, skin, and severe eye irritation has been demonstrated in experimental animals exposed to cyanuric chloride. Respiratory tract irritation occurred in exposed humans.
    1. In humans, repeated dermal exposure to low concentrations of cyanuric chloride did not cause irritation, although serious irritation and dermal necrosis have occurred in experimental animals exposed directly to the material.
    1. The similar compound, cyanuric chloride, caused corrosive damage to the gastrointestinal tract when fed at high doses to experimental animals. Subacute feedings of 37 mg/kg per day for 5 weeks caused no ill effects in rabbits.
    1. One older rat study without controls and using only a small number of animals found that cyanuric chloride is a relatively weak carcinogen, causing an increased incidence of fibroadenomas at injection sites, and tumors of the mammary glands, uterus, and prostate. This study has been criticized for several reasons, and does not provide adequate evidence that cyanuric chloride is carcinogenic.
  1. When cyanuric fluoride is heated to decomposition, highly irritating and toxic fumes of fluorides and oxides of nitrogen are released. Exposure to these products of combustion would be predicted to cause eye and respiratory tract irritation, and could lead to the development of chemical pneumonitis or noncardiogenic pulmonary edema.
  1. It is unknown whether or not systemic fluoride poisoning could occur following cyanuric fluoride absorption. However, it would be prudent to observe for such effects as hypocalcemia, hypomagnesemia, hyperkalemia, cardiac dysrhythmias, respiratory depression, hyperactive reflexes with tetany, and hypocoagulability.
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