RightAnswer Knowledge Solutions Search Results for 7440-48-4

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ACUTE EXPOSURE INFORMATION

1. The classic toxidrome of chronic soluble cobalt poisoning is the tetrad of goiter, polycythemia, cardiomyopathy, and metabolic acidosis.

2. INHALATION: Occupational inhalation exposure to metallic cobalt or cobalt alloys, usually produces cough, dyspnea, wheezing, asthma, or interstitial fibrosis ("hard metal disease"). Fume exposure can cause conjunctivitis and rhinitis.

3. DERMAL: "Cobalt itch" or "carboloy-itch" (an allergic erythematous papular eruption) may occur.

4. ORAL: "Beer drinker's cardiomyopathy" with frequent pericardial effusions have been described. Ingestion of cobalt can cause nausea, vomiting, and diarrhea. Ingestion of cobalt causes stimulation of the bone marrow and blood-forming components, resulting in polycythemia.

5. PARENTERAL: Rhabdomyosarcomas have been found in rats following intramuscular injections.

6. This management does not deal with potential clinical effects or treatment of radiation injury from radioactive cobalt isotopes. IF EXPOSURE TO RADIOACTIVE ISOTOPES OF COBALT HAS OCCURRED - refer to RADIATION MANAGEMENT for further information.

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