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• Alcohol, tobacco, and other drugs may harm the unborn.
• Alterations in septohippocampal cholinergic innervations and related behaviors after early exposure to heroin and phencyclidine.
• Behavioral effects of MK-801 exposure during development.
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Example Content from MEDITEXT for 77-10-1:


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ACUTE EXPOSURE INFORMATION

  1. USES: Phencyclidine (PCP, 1-(1-phenylcyclohexyl)-piperidine) is a dissociative anesthetic, and is abused for its hallucinogenic properties. It is related to ketamine, which is widely used as a sedation medication, but ketamine is much less potent than phencyclidine.
  1. TOXICOLOGY: Phencyclidine is thought to stimulate alpha-adrenergic receptors, potentiating the effects and/or inhibition of reuptake of norepinephrine, epinephrine, and serotonin. It is also thought to stimulate opioid receptors and inhibit NMDA receptors. In overdose, acute psychosis and sympathomimetic toxidrome can produce agitated delirium. In large overdoses, patients may progress to coma.
  1. EPIDEMIOLOGY: Exposure to phencyclidine is uncommon. Severe toxicity is rare. Deaths have been reported but are most often due to trauma rather than to direct drug effects.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Mild toxicity results in tachycardia, hypertension, hallucinations, euphoria, and disinhibition. Phencyclidine can also cause mild agitation and acute changes in mood. Nystagmus is often prominent on physical exam.
    1. SEVERE TOXICITY: Severe toxicity can cause psychosis, severe psychomotor agitation and hyperthermia. Rhabdomyolysis, multisystem organ failure, and metabolic acidosis can result from the hyperstimulation. Seizures, followed by coma and death are ultimate CNS outcomes in severe toxicity.
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