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Example Content from MEDITEXT for 7791-23-3:
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ACUTE EXPOSURE INFORMATION
- Selenious oxychloride dissociates into HYDROCHLORIC ACID and SELENIOUS ACID on contact with moisture. Its systemic toxicity is thus predicted to be similar to that of SELENIOUS ACID, as reflected in the following discussion. Selenious oxychloride may be absorbed following ingestion, inhalation, or dermal contact.
- Dermal application has resulted in systemic absorption. Eye contact can result in burns or irritation. Ingestion may result in severe burns of the mouth, esophagus, or gastrointestinal tract.
- Tachypnea, fever, initial hypertension followed by hypotension and shock, and tachycardia may be noted. Inhalation exposure may result in eye irritation or corneal burns and upper respiratory tract irritation. Pharyngeal edema, erosions, or burns may be noted in selenious acid ingestion exposure.
- Cardiovascular effects may include ECG abnormalities, dysrhythmias, cardiomyopathy, mild hypertension followed by significant hypotension and shock. Selenium oxychloride releases toxic and irritating fumes of chloride and selenium when heated to decomposition. Inhalation exposure to such fumes would be predicted to result in respiratory tract irritation with bronchospasm, chemical pneumonitis, or noncardiogenic pulmonary edema.
- CNS depression or coma may occur following selenious acid ingestion, inhalation, or dermal exposure. Seizures may occur. Restlessness was noted on presentation in a nonfatal case.
- Nausea, vomiting, diarrhea, and hematemesis may occur. Esophageal, pharyngeal, and gastrointestinal tract burns and erosions have been noted. Congestion and diffuse swelling of the liver and kidney, tubular injury, and small areas of papillary necrosis have been seen in fatal cases.
- Hematologic effects may include metabolic acidosis, thrombocytopenia, and elevated leukocyte counts. Weakness of skeletal muscles, including the diaphragm, may be severe and lead to respiratory failure requiring mechanical ventilation.
- Dermal exposures to selenium dioxide (selenium oxide) can produce dermatitis and vesiculation. Precipitation of small amounts of amorphous selenium in the tissues can cause a red staining of the fingers, teeth, and hair. Dermal burns can result from skin contact, and systemic absorption may occur through denuded areas. Necrotizing skin lesions can occur if selenium dioxide gets inside rubber gloves. If this compound penetrates beneath the free edge of the fingernails, excruciating pain may result.
- TOMES Plus system users may refer to the ACIDS and SELENIOUS ACID MEDITEXT Medical Management FOR MORE INFORMATION.
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