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ACUTE EXPOSURE INFORMATION

  1. o-Cresol is corrosive to tissues and can cause serious burns. It is rapidly absorbed by all routes and can be fatal by any route of exposure. Systemic effects include profound CNS depression, seizures, hemolysis, methemoglobinemia, pulmonary edema, and lung, liver, pancreas, spleen, heart, and kidney damage. Metabolic acidosis may occur.
  1. Skin contact is the main exposure route. Pain is followed by numbness; skin reddens, then blanches, blisters, and forms a scab. Skin contact can result in severe skin burns. Eye contact produces irritation, redness, corneal burns, keratitis, and possibly, in severe cases, blindness.
  1. Inhalation produces coughing and labored, fast breathing; respiratory failure may result. Ingestion causes a burning pain in the mouth and throat, and abdominal pain, nausea, vomiting, bloody diarrhea and collapse. White necrotic lesions of the mouth, throat and stomach are also seen.
  1. Other exposure symptoms include confusion, pallor, sweating, weakness, headaches, dizziness, tinnitus, shock (weak irregular pulse, shallow breathing, cyanosis, pallor), seizures, unconsciousness, collapse, coma and death from heart and lung failure. Kidney damage results in scant, dark, 'smoky' urine and impaired renal function.
  1. Chronic exposure may produce allergic dermatitis, digestive disturbances, CNS effects, and liver and kidney damage. Effects may include vomiting, diarrhea, anorexia, difficulty swallowing, excessive salivation, diarrhea, loss of appetite, headache, fainting, dizziness, mental disturbances, skin rash, or death from severe damage to the liver or kidneys.
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