RightAnswer Knowledge Solutions Search Results for Azacitidine

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• 2'-Deoxy-5-azacytidine and hind limb phocomelia in the CD-1 mouse.
• 5-Azacytidine-induced apoptosis in the central nervous system of developing rat fetuses.
• A bioassay that identifies postnatal functional deficits in mice prenatally exposed to xenobiotics.
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Example Content from MEDITEXT for Azacitidine:


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ACUTE EXPOSURE INFORMATION

  1. USES: Azacitidine is indicated for the treatment of various myelodysplastic syndrome subtypes including refractory anemia with or without ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia.
  1. PHARMACOLOGY: Appears to restore normal growth and differentiation of bone marrow cells by causing hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow. Hypomethylation may permit the normal functioning of genes that regulate differentiation and proliferation.
  1. EPIDEMIOLOGY: Overdoses are rare.
  1. WITH THERAPEUTIC USE
    1. COMMON: The most commonly occurring events (greater than 30%) following use include effects related to myelosuppression (ie, neutropenia, thrombocytopenia, anemia), fatigue, pyrexia, gastrointestinal symptoms (ie, nausea, vomiting, constipation or diarrhea), injection site reactions, petechiae, and hypokalemia.
    1. LESS FREQUENT: Other effects occurring less frequently include hypotension, myocarditis, mucositis, renal dysfunction, hepatic abnormalities, myalgias, rhabdomyolysis, headache, dyspnea, and coma.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Gastrointestinal effects (nausea, vomiting, diarrhea) occurred following administration of a single IV dose of approximately 290 mg/m(2), approximately 4 times the recommended starting dose.
    1. SEVERE TOXICITY: Severe toxicity following overdose has not been reported. It is anticipated that clinical effects will likely be an extension of adverse events (ie, myelosuppression, fatigue, nausea, vomiting, diarrhea).
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