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• [Effect of copper and zinc on embryos, larvae and adult individuals of the sea urchin Strongylocentrotus intermedius and the sea cucumber Stichopus japonicus]
• [Effects of perinatal lead intervention on development of newborn's nervous behavior]
• [Role of copper in process of embryonal development]

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• [Teratogenic effects of copper on chironomid larvae]
• A comparison of reproduction, growth and acute toxicity in two populations of Tubifex tubifex (Müller, 1774) from the North American Great Lakes and Northern Spain.
• Abnormal Yolk Sac Vasculature and Decreased Nitric Oxide in Copper Deficient Mouse Embryos.
• Alterations in development resulting from nutrient imbalance.
• Altered energy metabolism is an additional factor contributing to copper (Cu) deficiency-induced teratogenesis.
• Altered nitric oxide availability contributes to copper deficiency-induced teratogenicity.
• Analysis of the drinking water of mothers of neural tube defect infants and of normal infants for 14 selected trace elements by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS).
• Analytic study to evaluate associations between hazardous waste sites and birth defects--final report.
• Brindled mutant mice: effects of maternal copper administration on fetal and neonatal cerebrum.
• Cadmium (Cd) and metallothionein (MT) content of normal human placenta and in rats placentas and offspring given Cd during gestation.
• Capacity adaptation of Hediste (Nereis) diversicolor embryogenesis to salinity, temperature and copper.
• Cardiac mitochondrial function is altered in the adult offspring of copper-deficient dams.
• Cellular and molecular targets of benzo(a)pyrene and metal toxicity in Xenopus laevis embryos and in Hep G2 cells.
• Changes in activity of certain enzymes in sea urchin embryos and larvae after exposure of adult organisms to heavy metals.
• Combined effect of high-fat diet and copper deficiency during gestation on fetal copper and iron nutritional status, in the rat.
• Comparative developmental toxicity of metals to embryo-larval stages of aquatic organisms.
• Comparative effects of essential and nonessential metals on preimplantation mouse embryo development.
• Comparative toxicities of trace metals on embryos of the giant clam, Tridacna derasa.
• Congenital anomalies and tissue specificity of metals: triethylene tetramine dihydrochloride as a chelating drug of copper.
• Contaminants in American alligator eggs from Lake Apopka, Lake Griffin, and Lake Okeechobee, Florida.
• Copper (Cu) Deficiency Alters Mouse Embryonic and Yolk Sac Vasculature and Expression of Angiogenic Mediators.
• Copper deficiency in mice increases hepatic iron stores but does not up-regulate expression of the iron exporter Ferroportin-1.
• Copper deficiency in neonatal mice alters brain catecholamine levels.
• Copper deficient mouse embryos are characterized by abnormal yolk sac vasculature and decreased nitric oxide.
• Copper hazards to fish, wildlife, and invertebrates: a synoptic review.
• Copper toxicity to sperm, embryos and larvae of topsmelt Atherinops affinis, with notes on induced spawning.
• Cu deficiency alters cardiovascular structure and extracellular matrix (ECM) protein expression during murine development.
• Cu deficiency induces oxidative damage in mouse embryos.
• Determination of some elements in erythrocytes and placenta in upper Silesia (Poland) using ICP-MS.
• Development of whole-embryo limb development assay using Xenopus laevis.
• Developmental effects of copper complexes.
• Developmental toxicity of copper chloride, methylene chloride, and 6-aminonicotinamide to embryos of the grass shrimp Palaemonetes pugio.
• Diagnosis and possible prevention of the onset of symptoms in brindled hemizygous fetuses.
• Distribution of heavy metals in the eggs and hatchlings of olive ridley sea turtle, Lepidochelys olivacea, from Gahirmatha, Orissa.
• Effect of high levels of copper or dichlorvos during late gestation and lactation on sow productivity.
• Effect of new copper complex on embryogenesis in mice.
• Effect of zinc and copper on preimplantation mouse embryo development in vitro and metallothionein levels.
• Effects of copper nutrition on diabetic pregnancy outcome in rats.
• Effects of copper on life-history traits of Daphnia pulex and Bosmina longirostris.
• Effects of copper on survival, development and growth of Metapenaeus ensis larvae and postlarvae (Decapoda: Penaeidae).
• Effects of copper on the 48-h embryonic development of the bivalve Scrobicularia plana.
• Effects of environmental metal pollution on breeding populations of pied and collared flycatchers in NiepoÈlomice Forest, Southern Poland.
• Effects of maternal smoking on placental trace element content.
• Effects of teratogenic concentrations of Zn2+, Cd2+, Ni2+, Co2+, and Cu2+ in FETAX assays on metallothionein (MT) and MT-mRNA contents of Xenopus laevis embryos.
• Effects of toxicants on developing oocytes and embryos of the blue crab, Callinectes sapidus.
• Effects of water pH on copper toxicity to early life stages of the common carp (Cyprinus carpio).
• Egg shell quality, clutch size and hatching success of the great tit (Parus major) and the pied flycatcher (Ficedula hypoleuca) in an air pollution gradient.
• Embryonic and larval development of brown trout, Salmo trutta L.: exposure to aluminium, copper, lead or zinc in soft, acid water.
• Embryonic and larval development of brown trout, Salmo trutta L.: exposure to trace metal mixtures in soft water.
• Embryonic cell death patterns are different in embryos from zinc (Zn) deficient dams compared to embryos from copper (Cu) deficient, and diabetic dams.
• Essential and non-essential metals in fetuses and infants.
• Formation of copper complexes in landfill leachate and their toxicity to zebrafish embryos.
• Functional damage in the developing brain induced by maternal environmental agents.
• Functional damage in the developing brain induced by maternal environmental agents: ethanol, tobacco and low-copper level.
• Gestational Diabetes Is Associated With Increased Resistance Of Serum Lipids To Copper Induced Peroxidation In Vitro Indicating Low Oxidative Stress.
• Gestational smoking and the placental content of essential metals.
• Gestational smoking and the placental content of essential metals.
• Gestational smoking and the placental content of essential trace metals.
• Hatching glands of carp (Cyprinus carpio L.) embryos from the eggs incubated at various concentrations of zinc or copper.
• Heavy metal content in liver and kidneys of grey seals (Halichoerus grypus) in various life stages correlated with metallothionein levels: some metal-binding characteristics of this protein.
• Impact of maternal trace element status on outcome of pregnancy.
• Impact of perinatal copper (CU) deficiency on rat dopamine beta-monooxygenase (DBM).
• Incidence and impact of axial malformations in larval bullfrogs (Rana catesbeiana) developing in sites polluted by a coal-burning power plant.
• Incubation of fertilized common carp (Cyprinus carpio L.) eggs in different concentrations of copper.
• Investigating the Cellular Defects of Copper Deficiency Mediated Impaired Angiogenesis During Mouse Development.
• Issues of human exposure to agents causing developmental toxicity.
• Lead accumulation and osprey production near a mining site on the Coeur d'Alene River, Idaho.
• Limited effects of heavy metal pollution on foraging and breeding success in the curlew (Numenius arquata).
• Low Nitric Oxide Availability is a Key Factor Underlying Copper Deficiency Teratogenicity.
• Low serum copper level and neural tube defect: A case control study.
• Low-protein diet in the rat: effect on fetal copper (Cu) status and placental transport.
• Marginal Copper Deficiency In Pregnancy: Vascular Responses In Dams And Progeny.
• Maternal diabetes and maternal copper deficiency result in increased oxidative damage (DNA-protein crosslinks) in gestation day 11.0 rat embryos.
• Maternal hair zinc, copper and magnesium concentration in neural tube defects in Turkey.
• Maternal iron deficiency affects fetal growth, iron and copper metabolism.
• Maternal iron, Copper, Magnesium and Calcium Levels in Preterm Delivery and the Effect of These Trace Elements on Birth Weight.
• Maternal micronutrients and short inter-pregnancy interval.
• Maternal serum magnesium in non diabetic and diabetic women: association with spontaneous abortion.
• Maternal trace elements and fetal congenital malformations.
• Maternal trace elements, vitamin B12, viatmin A, folic acid and fetal malformations.
• Maternal trace elements, vitamin B12, vitamin A, folic acid and fetal malformations.
• Maternal trace elements, vitamin B12, vitamin A, folic acid and fetal malformations.
• Maternal trace elements, vitamine B12, vitamine A, folic acid and fetal malformations.
• Meconium analysis using AAS for screening the intrauterine exposure to heavy metals in an ecological disaster region.
• Micronutrients and pregnancy outcome: a review of the literature.
• Modifying factors in prenatal carcinogenesis (review).
• Modulation of cupric ion activity by pH and fulvic acid as determinants of toxicity in Xenopus laevis embryos and larvae.
• Nutritional considerations in developmental neuraltoxicity.
• Oral developmental toxicity study of ammonium tetrathiomolybdate (NSC-714598) in rabbits.
• Oxidative damage as a potential mechanism contributing to Cu deficiency-induced defects in rat embryos.
• Pax3: control of DNA binding by redox status, metals and nitrogen oxide species.
• Pb, Cd, Zn and Cu concentrations in human neonatal bones and livers measured by pulse differential polarography.
• Perinatal effects of iron-, ascorbate-induced hypocuprosis: implications for sudden infant death.
• Placental iron, zinc and copper concentrations and pregnancy outcome.
• Prenatal Cu intake by rat dams is the principle determinant of cardiac cytochrome c oxidase activity in their offspring.
• Relationship of maternal trace element nutriture with pregnancy outcome in Kuwait.
• Reproductive allocation in the terrestrial isopods Porcellio scaber and Oniscus asellus in a metal-polluted environment.
• Respiratory distress in copper deficiency. An experimental model developed in rats.
• Serum Copper Concentrations in Pregnant African-American Adolescents.
• Serum zinc and copper concentrations in pregnant women from Kuwait.
• Spatial and temporal trends of contaminants in eggs of wading birds from San Francisco Bay, California.
• Spermiotoxicity and embryotoxicity of heavy metals in the echinoid Paracentrotus lividus.
• Teratogenic effects of insufficient boron, copper, and zinc in Xenopus.
• Teratogenic effects of ionizing radiation and chemical substances.
• Teratogenicity of metals to chick embryos.
• Term Premature Rupture Of The Membranes Is Not Associated With Increased Susceptibility Of Maternal Serum Lipids To Copper Induced Peroxidation.
• The developmental toxicity of tetrathiomolybdate (TTM, NSC-714598) and protective effects of copper in rats.
• The effect of copper on common carp (Cyprinus carpio L.) during embryonic and postembryonic development.
• The effect of copper on the embryonic development and hatching of Sepia officinalis L.
• The effect of in utero hypoxia on fetal heart and brain trace metals.
• The effect of maternal triethylene tetramine dihydrochloride on the mouse fetus.
• The effects of maternal training on plasma copper, magnesium and zinc in rats.
• The effects of tetrathiomolybdate (TTM, NSC-714598) and copper supplementation on fertility and early embryonic development in rats.
• The effects of trichlorfon, praziquantel and copper sulphate on various stages of the monogenean Benedeniella posterocolpa, a skin parasite of the cownose ray, Rhinoptera bonasus (Mitchill).
• The general and reproductive toxicity of the photovoltaic material copper gallium diselenide (CGS).
• The general and reproductive toxicity of the photovoltaic material copper indium diselenide (CIS).
• The physiological significance of copper (Cu) in pregnancy (1)--metal metabolism within internal organs of newborn and pregnant rats fed on low copper feed.
• The role of dietary molybdenum on estrous activity, fertility, reproduction and molybdenum and copper enzyme activities of female rats.
• The role of trace elements in bovine abortion.
• The Teratogenic Effect Of Copper Chloride (II) On Neural Tube Development Of Mouse Embryos By Emphasizing On Cervical Spinal Cord.
• Toxic effect of zinc smelter effluent to some developmental stages of freshwater fish, Cyprinus carpio (Linnaeus).
• Toxicity and teratogenicity of some metals in chick embryos.
• Toxicity of metals and low pH to embryos and larvae of the Jefferson salamander, Ambystoma jeffersonianum.
• Toxicity to embryo and adult zebrafish of copper complexes with two malonic acids as models for dissolved organic matter.
• Trace element (zinc, copper, iron and magnesium) concentrations in human placenta and their relationship to birth weight of babies.
• Trace minerals in pregnancy. 1. copper and zinc.

ECOTOX Documents

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HSDB® Data Bank

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LOLI® Listings

• Copper ( 133353-46-5)
• Copper ( 133353-47-6)
• Copper ( 195161-80-9)
• Copper ( 65555-90-0)
• Copper ( 72514-83-1)
• Copper ( 7440-50-8)
• Copper compounds ( RR-00595-8)

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RTECS® Registry

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Shepard's Catalog

• Copper Deficiency and Excess

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(19437) English MSDSs - (click to search other languages)

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Example Content from MEDITEXT for Copper:

ACUTE EXPOSURE INFORMATION

1. WITH POISONING/EXPOSURE
   1. ROUTES OF EXPOSURE - Copper compounds may be toxic by inhalation, ingestion, injection, and skin or eye exposure. Copper salts are particularly irritating.
   2. INHALATION - Exposure to fumes or dust may cause irritation of the nose and upper respiratory tract, as well as sneezing and coughing. Perforation of the nasal septum can also occur. 'Metal fume fever,' with respiratory and flu-like symptoms such as chills and muscle aches, may result from exposure to fumes or fine dust. The incidence of copper-induced metal fume fever is low due to the high temperatures required to volatilize copper.
   3. INGESTION - Acute ingestion of copper salts can cause irritation, severe nausea and vomiting, salivation, abdominal pain, epigastric burning, hemolysis, gastrointestinal bleeding with hemorrhagic gastritis, hematemesis and melena, anemia, hypotension, jaundice, seizures, coma, shock and death. Hepatic and renal failure may develop several days after acute ingestion. Methemoglobinemia may rarely occur. Copper may produce a metallic or sweet taste.
   4. INJECTION - Subcutaneous injection of copper glycinate resulted in nausea and vomiting, acute renal failure, hemolytic anemia, acute hepatic failure, disseminated intravascular coagulation, and dermal necrosis at the injection site.
   5. DERMAL - Skin exposure may cause irritation, itching, eczema, allergic contact dermatitis, hypersensitivity, and a greenish discoloration of the hair, teeth and skin.
   6. EYE - Exposure of the eyes to copper fumes or dust can cause irritation, conjunctivitis, palpebral edema, ulceration and corneal turbidity. Eye irritation, uveitis, abscess and loss of the eye may also occur from the mechanical action of lodged copper particles. Penetration of the eye by fine fragments can result in severe ocular damage. Corneal discoloration (Kayser-Fleischer ring) is a hallmark of Wilson disease.