RightAnswer Knowledge Solutions Search Results for Cyclobenzaprine

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ACUTE EXPOSURE INFORMATION

  1. USES: A skeletal muscle relaxant used for pain relief in acute musculoskeletal conditions.
  1. PHARMACOLOGY: Inhibition of alpha and gamma motor neurons via the brain stem.
  1. TOXICOLOGY: Displays anticholinergic, antihistaminergic, and CNS depressant effects in overdose. It is also a weak norepinephrine and serotonin reuptake inhibitor.
  1. EPIDEMIOLOGY: Poisoning is common but rarely severe.
  1. WITH THERAPEUTIC USE
    1. Sedation, flushing, dry mouth, and hallucinations.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE POISONING: Sedation, anticholinergic effects (ie, mydriasis, flushing, fever, dry mouth, decreased bowel sounds, hallucinations), sinus tachycardia, mild hypertension or hypotension, and nausea and vomiting are common after overdose.
    1. SEVERE POISONING: Severe effects may include significant hypotension, respiratory depression, and coma. Cyclobenzaprine is a cyclic amine with structural similarity to the tricyclic antidepressant amitriptyline. Therefore, theoretically, conduction delays and ventricular dysrhythmias are of concern but are exceedingly rare even in large overdoses.
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