RightAnswer Knowledge Solutions Search Results for Disulfiram

RightAnswer Knowledge Solutions provides access to hundreds of data sources. Our premier and proprietary sources include fully-researched documents from well-established experts in the chemical and HazMat fields.

A search in our system for this chemical would return results – all in one place -- in the following categories from the listed data sources.

---

RightAnswer Proprietary Data Sources:

---

All Other Data Sources:

---

ChemID External Links:

---

Other Government Links Searched via RegsKnowledge:

Example Content from MEDITEXT for Disulfiram:

Please note: this is an extract of information from a larger document. Full document and details are available by subscription.

ACUTE EXPOSURE INFORMATION

1. USES: Disulfiram also known as antabuse or tetraethylthiuram disulfide (TETD) is used as an industrial antioxidant, fungicide, disinfectant, and most commonly to maintain sobriety in patients with chronic ethanol abuse. This document discusses toxicity related to disulfiram overdose. Please refer to ETHANOL-DISULFIRAM REACTION or DISULFIRAM-LIKE REACTION documents for more information regarding adverse events from interactions with ethanol.

2. PHARMACOLOGY: Disulfiram inhibits aldehyde dehydrogenase and dopamine betahydroxylase which leads to inhibition of alcohol oxidation at the acetylation stage and results in high levels of acetaldehyde and produces a disulfiram-alcohol reaction.

3. TOXICOLOGY: Disulfiram-induced inhibition of dopamine betahydroxylase results in norepinephrine depletion at presynaptic sympathetic nerve endings. The carbon disulfide metabolite (industrial solvent & pesticide) of acetaldehyde may cause the CNS and peripheral nerve toxicity associated with disulfiram.

4. EPIDEMIOLOGY: Disulfiram overdose alone is uncommon and severe manifestations of toxicity are rare.

5. WITH THERAPEUTIC USE
   1. COMMON: Metallic taste, garlic/sulfur/acetone odor, nausea, vomiting, headache, drowsiness, and ataxia.
   2. RARE: Dermatitis, liver injury (may progress to fulminant hepatic failure), seizure, neuropathy, encephalopathy, and optic neuritis.

6. WITH POISONING/EXPOSURE
   1. MILD TO MODERATE TOXICITY: Nausea, vomiting, abdominal pain, diarrhea, odor of sulfur, acetone, or garlic, headache, lethargy, weakness, tachypnea, ketosis, ataxia, hypotension, and tachycardia may develop.
   2. SEVERE TOXICITY: Psychosis, hallucinations, ataxia, seizures, extrapyramidal movement disorders, paralysis, encephalopathy, coma, cardiovascular collapse, hypotension, cardiogenic shock, and sensorimotor neuropathy have been reported.
   3. CHRONIC DISULFIRAM TOXICITY: Headache, drowsiness, seizures, neuropathy, and dermatitis. Occasionally implicated in producing psychosis, optic neuritis, and encephalopathy. Hematologic, neuromuscular, and gastrointestinal toxicity and hepatotoxicity may occur 10 days to 12 months after therapy has begun. Toxic or hypersensitivity hepatitis, including death, has been reported. Fatal hepatic necrosis following six weeks of disulfiram therapy (250 mg/day) has also been reported. Effects appear at highly variable time intervals ranging from weeks to years of treatment.

© 2011-2025 RightAnswer.com, Inc. and/or its licensors. All rights reserved. No claim to original U.S. Govt. works.