RightAnswer Knowledge Solutions Search Results for Indomethacin

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• INDOMETHACIN

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• INDOMETHACIN

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• [A study of fetal ductus arteriosus constriction by E5510 in rats]
• [Study on the constriction of fetal ductus arteriosus by a lipid emulsion of 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate (LFP 83) in rats]
• [The threatened premature labour and its treatment]

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• A RCT of indomethacin for preterm labor: effects on fetal heart and ductus arteriosus.
• A systematic review of the effects of dopamine on the renal side effects of indomethacin in the premature newborn infant.
• Administration of prostaglandin inhibitors to the mother; the potential risk to the fetus and neonate with duct-dependent circulation.
• Adverse neonatal outcomes following antenatal indomethacin use.
• Age-related expression of the placental iNOS mRNA and its possible role in regulating the ductus arteriosus patency in fetal rats.
• Animal models of ascending genital-tract infection in pregnancy.
• Antenatal indomethacin and white matter injury in preterm infants.
• Antenatal visualization of malformations associated with drugs and chemicals.
• Antioxidants and oxidative stress injuries to the brain in the perinatal period.
• Chemical-induced alterations of sexual differentiation: a review of effects in humans and rodents.
• Combined use of indomethacin and dexamethasone does not increase the risk for spontaneous intestinal perforation in premies less than 1000 gms.
• Constrictive effects of indomethacin, paraquat and diquat on the ductus arteriosus in fetal rats.
• Counteraction of the embryolethal effects, but not the maternal toxicity, of bropirimine and tilorone by coadministration of indomethacin.
• Delayed reproductive effects following exposure to toxic chemicals during critical developmental periods.
• Delayed reproductive effects following exposure to toxic chemicals during critical developmental periods.
• Dilating effect of prostaglandin on the constricted ductus arteriosus in newborn rats following maternal treatment with indomethacin.
• Disposition kinetics in the rat fetus.
• Does indomethacin administered at the time of ultrasound-indicated cerclage prevent spontaneous preterm birth?
• Drug therapy in pregnancy and lactation.
• Drug treatment in perinatal period and neuro-psycho-immuno-competence in adulthood and senescence.
• Early ductal closure in 12 neonates born from mothers given indomethacin.
• Early fetal exposure to long-term indomethacin therapy to prevent preterm delivery: neonatal outcome.
• Effect of a COX-2 inhibitor, rofecoxib, on closure of the fetal rat ductus arterious.
• Effect of Antenatal Indomethacin on Neonatal Outcomes: Meta-Analysis of Observational Studies.
• Effect of indanyl analogues of diethylstilboestrol on morphological transformation of Syrian hamster embryo fibroblasts and micronuclei in vitro.
• Effects of indomethacin (INDO) on fetal breathing movements (FBM) in humans.
• Effects of indomethacin administered during late-gestation on splenic lymphocyte subsets in rat pups.
• Effects of indomethacin and angiotensin II on fetal renal function.
• Effects of indomethacin and hypotension upon cerebral blood flow (CBF) and oxygen metabolism (CMRO2) in the preterm lamb.
• Effects of nonsteroidal anti-inflammatory agents on implantation in rats.
• Effects of tocolytic indomethacin on neonatal renal function.
• Effects of tocolytic indomethacin on neonatal renal function.
• Effects of tocolytic indomethacin on neonatal renal function.
• Efficacy and safety of indomethacin vs. magnesium sulfate in the management of preterm labor: a randomized study.
• Enhanced in vitro covalent binding of [3H]-phenytoin catalysed by linoleic acid-dependent soybean lipoxygenase.
• Evaluation of perinatal complications of tocolytic use of indomethacin.
• Exposure to indomethacin in utero does not result in adverse neonatal outcome.
• Featl indomethacin syndrome.
• Fetal cardiovascular effect of betamethasone combined with indomethacin in rats during midtrimester.
• Fish embryotoxicity and teratogenicity of pharmaceuticals, detergents and pesticides regularly detected in sewage treatment plant effluents and surface waters.
• Focal Necrotizing Enterocolitis Among Premature Infants With Prenatal Indomethacin Exposure.
• Functional teratogenicity of indomethacin and dexamethasone induced by neonatal administration in rats.
• Further evaluation of a teratogenicity screen using an intravitelline injection technique.
• Gestational age determines ductal constriction with indomethacin.
• Gestational age modifies ovine fetal responses to indomethacin.
• Human fetal blood flow velocity redistribution at cardiac level due to indomethacin.
• Human immunodeficiency virus-associated nephropathy in pregnancy.
• In vitro embryotoxicity of the pesticide aminocarb in organogenesis stage rat conceptuses.
• In vitro micromass teratogen test: interpretation of results from a blind trial of 25 compounds using three separate criteria.
• In vitro micromass teratogen test: results from a blind trial of 25 compounds.
• Incidence of indomethacin-induced human fetal ductal constriction.
• Incidence of indomethacin-induced human fetal ductal constriction.
• Indomethacin Affects Ovarian Function: An In Vitro Mouse Study.
• Indomethacin causes placental vasodilation.
• Indomethacin influences arginine vasotocin-induced parturition and oviposition in lizards (Sceloporus jarrovi and Sceloporus undulatus).
• Indomethacin modifies the fetal hemodynamic response induced by cordocentesis.
• Indomethacin Suppression of MMP Activity and VEGF Levels in Fetal Rabbit Lungs.
• Indomethacin tocolysis is not associated with an increased incidence of isolated bowel perforations in premature neonates.
• Indomethacin treatment of acute polyhydramnios: retrospective study of 36 cases.
• Indomethacin-induced placental vasodilation: association with fetal ductal constriction.
• Induction of hepatic metallothionein by salicylate in adult rats.
• Inhibitors of eicosanoid biosynthesis and their effect upon Bacillus thuringiensis delta-endotoxin response in cultured insect cells and developing larvae.
• Intracranial haemorrhage in premature neonates.
• Intravitelline injection of rodent conceptuses: an improved in vitro developmental toxicity screen.
• Is In Utero Exposure To Indomethacin Associated With Increased Incidence Of Neonatal Complications?
• Is maternally administered selective cyclooxygenase (COX)-2 inhibitor nephrotoxic in fetal rats?
• Is there justification for using indomethacin in preterm labor? An analysis of neonatal risks and benefits.
• Long-term and short-term childhood health after long-term use of indomethacin in pregnancy.
• Management of asthma during pregnancy.
• Maternal Administration of Oral Indomethacin Increases Pulmonary Nitric Oxide and Endothelin-1 Levels in Fetal Rabbits.
• Neonatal complications after antenatal indomethacin for preterm labor.
• Neonatal complications associated with indomethacin tocolysis in very preterm infants.
• Neonatal complications associated with prenatal use of indomethacin.
• Neonatal effects after antenatal treatment with indomethacin vs. sulindac.
• Neonatal morbidity in newborns from mothers treated with indomethacin.
• Neonatal outcome with exposure to indomethacin in early gestation as compared to late gestation.
• Neonatal Outcomes In Very Low Birth Weight (VLBW) Infants Exposed To Antenatal Indocin Versus Sulindac.
• Neonatal Outcomes in Very Low Birth Weight Infants Exposed to Antenatal NSAIDS.
• Neurodevelopmental Outcome After Antenatal Indomethacin Exposure.
• Neurodevelopmental outcome of infants exposed to antenatal indomethacin.
• Nitric oxide inhibits closure of the ductus arteriosus following antenatal exposure to indomethacin.
• Nitric oxide regulates tone of the ductus arteriosus, pulmonary artery and aorta in the fetal rat.
• Nonsteroidal anti-inflammatory drugs and the incidence of retinopathy of prematurity in very low birth weight infants.
• Outcome of infants exposed to indomethacin antenatally: a case control study.
• Outcomes of very low birth weight infants exposed to antenatal indomethacin for tocolysis.
• Perinatal factors predicting severe intracranial hemorrhage.
• Placental transfer of drugs and fetal risks.
• Plasma atrial natriuretic factor and arginine vasopressin responses to indomethacin in the ovine fetus.
• Postnatal renal function (RF) in premature infants following in-utero (IU) indocin (IN) exposure.
• Pre and postnatal effects of prenatal indomethacin.
• Pre and postnatal effects of prenatal indomethacin.
• Pregnancy in women with myoma uteri.
• Prenatal beta-mimetic exposure of the newborn: maternal oral vs. continuous infusion therapy.
• Prenatal cigarette smoke exposure leads to aberrant vascular smooth muscle responses during adult life.
• Prenatal cocaine exposure is associated with postnatal indomethacin failure to close the ductus arteriosus in VLBW babies.
• Prenatal exposure to indomethacin is associated with a decreased incidence of persistent ductus arteriosus.
• Preterm birth prevention programs and other interventions to decrease preterm birth in multiple gestations.
• Prospective safety and developmental analysis of neonates exposed to a selective cyclooxygenase-2 (COX-2) inhibitor in utero.
• Randomized comparative trial of indomethacin and terbutaline for the long term treatment of preterm labor.
• Reduced fetal movements and maternal medication -- new pregnancy risk factors for neurodevelopmental disability in childhood.
• Reduction Of Very Low Birth Weight Rate In Twin Pregnancies.
• Reversal of bropirimine embryolethality with progesterone or indomethacin.
• Reversal of tilorone embryo-lethality with progesterone or indomethacin.
• Safety of non-steroidal anti-inflammatory drugs during pregnancy and lactation.
• The adverse renal effects of prostaglandin-synthesis inhibition in the fetus and the newborn.
• The association of prenatal indomethacin exposure and severe intraventricular hemorrhage (IVH) in extremely premature infants.
• The effect of gestational age and fetal indomethacin levels on the incidence of constriction of the fetal ductus arteriosus.
• The effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus in the newborn.
• The effect of indomethacin on fetal heart biometry.
• The effect of indomethacin on fetal lung growth and maturation in the rabbit model.
• The effect of indomethacin tocolysis of preterm labor on perinatal outcome: a RCT.
• The effect of tocolytic agents (indomethacin and terbutaline) on fetal breathing (FBM) and body movements (FM): a prospective, randomized, double blind, placebo-controlled clinical trial.
• The Effects of In Utero Tobacco Smoke Exposure and Indomethacin Treatment of Patent Ductus Arteriosus on Chronic Lung Disease of Infancy and Urinary Leukotriene E4 Levels.
• The Effects Of Indomethacin On Chick Embryonic Angiogenesis.
• The effects of indomethacin on maternal and fetal renal histology in rabbits.
• The effects of maternal indomethacin therapy on the human fetal branch pulmonary arterial vascular impedance.
• The embryonic stem cell test, an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells.
• The relationship of indomethacin and prostaglandin E2 to the ethanol-induced suppression of ovine fetal breathing movements.
• The Role Of Coagulation During Lps-Induced Preterm Delivery.
• The safety of long-term indomethacin therapy.
• The stem-cell test -- a novel in vitro assay for teratogenic potential.
• The stem-cell test: an in vitro assay for teratogenic potential. Results of a blind trial with 25 compounds.
• The study of potency of rat whole embryo culture for teratogens.
• Tocolysis with indomethacin is associated with patent ductus arteriosus (PDA) refractory to therapy.
• Vaginal Indomethacin Effectively Prolongs Gestation In A Rabbit Model For RU486-Induced Preterm Birth Without Adverse Maternal And Fetal Renal Prostanoid Effects.
• Vaginal Indomethacin Favorably Suppresses Certain Pro-Inflammatory Cytokines And Prolongs Gestation In A Rabbit Model For RU486-Induced Preterm Birth.
• Vaginal Indomethacin Increases Uterine Progesterone Receptor Beta And Prolongs Gestation In A Rabbit Model For RU486-Induced Preterm Birth In Rabbits.
• Vascular function in the virgin and pregnant offspring of diabetic rats.
• Very Low Birth Weight (VLBW) Infants Response to Indomethacin (INDO) Therapy for Patent Ductus Arteriosus (PDA) Following In Utero Exposure to INDO.
• Why does antenatal indomethacin produce hypoxia in the fetal ductus arteriosus?

ECOTOX Documents

• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

GENE-TOX Documents

• INDOMETHACIN

HSDB® Data Bank

• INDOMETHACIN

LOLI® Listings

• Indomethacin ( 37242-43-6)
• Indomethacin ( 503560-73-4)
• Indomethacin ( 53-86-1)
• Indomethacin ( 91853-74-6)

REPROTOX® Documents

• INDOMETHACIN

RTECS® Registry

• Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-

Shepard's Catalog

• Indomethacin

TERIS Documents

• INDOMETHACIN

MSDSonline®

(135) English MSDSs - (click to search other languages)

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Example Content from MEDITEXT for Indomethacin:

ACUTE EXPOSURE INFORMATION

1. USES: Used as an analgesic, antipyretic, and antiinflammatory drug to treat a wide range of pain and inflammatory conditions such as gout, pericarditis, several arthritis conditions, and dysmenorrhea. It is used in neonates for treatment of patent ductus arteriosus.

2. PHARMACOLOGY: Inhibits cyclooxygenases, COX1 and COX2. This results in the decreased synthesis of prostaglandins, thromboxane A2, and decreased pain and inflammation.

3. TOXICOLOGY: GI: Indomethacin is a direct GI irritant, and the inhibition of prostaglandin synthesis interferes with the maintenance of the GI barrier. Inhibition of thromboxane A2 in platelets prolongs bleeding time and predisposes to GI bleeding. RENAL: Decreases in prostaglandins I2 and E2, which have vasodilatory and natriuretic effects in the kidney that can lead to salt and water retention, and renal failure.

4. WITH THERAPEUTIC USE
   1. COMMON: Nausea, vomiting, gastritis, GI ulceration with perforation and hemorrhage, frontal headache, LESS COMMON: Dizziness, vertigo, stupor, hypersensitivity reactions, renal insufficiency, neutropenia, thrombocytopenia, and aplastic anemia.

5. WITH POISONING/EXPOSURE
   1. MILD TO MODERATE TOXICITY: Nausea, vomiting, and mild abdominal pain may develop.
   2. SEVERE TOXICITY: CNS disorientation, mental confusion, and lethargy have been reported. Upper GI bleeding and acute renal failure are also possible.