RightAnswer Knowledge Solutions Search Results for Milnacipran

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Example Content from MEDITEXT for Milnacipran:


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ACUTE EXPOSURE INFORMATION

  1. USES: Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used in the management of fibromyalgia.
  1. PHARMACOLOGY: Inhibits neuronal norepinephrine and serotonin reuptake; thus potentiating the serotonergic and noradrenergic activity in the CNS.
  1. TOXICOLOGY: Primarily sympathomimetic activity, potential for serotonin syndrome.
  1. EPIDEMIOLOGY: Several deliberate poisonings have been reported in postmarketing experience. Fatalities are rare.
  1. WITH THERAPEUTIC USE
    1. COMMON: Headache, nausea and vomiting, constipation, hypertension, tachycardia and palpitations. Elevated liver enzymes have been reported.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Somnolence, nausea and vomiting are common. Tachycardia and hypertension have been reported.
    1. SEVERE TOXICITY: Milnacipran may cause seizures and serotonin syndrome. Acute stress cardiomyopathy developed in a woman after ingesting 3000 mg of milnacipran.
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