RightAnswer Knowledge Solutions Search Results for Toluene 2,6-diisocyanate

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ACUTE EXPOSURE INFORMATION

1. Toluene 2,6-diisocyanate (2,6-TDI) is usually the minor component of a mixture with the 2,4- isomer, and their toxicity is believed to be similar.

2. The main route of toxic exposure to 2,6-TDI is by inhalation; ingestion also occurs, and it can be absorbed through the skin. It is a strong irritant of the eyes, nose, skin and respiratory tract. At high concentrations, the vapor may induce bronchoconstriction by a pharmacologic mechanism. The most recognizable effect of overexposure is an asthma-like reaction.

3. The sequence of effects is conjunctival irritation and lacrimation, with pharyngeal irritation, followed by a dry cough in the evening, with retrosternal chest pain, difficulty breathing and distress; this worsens at night and is better in the morning. Re-exposure produces coughing, chest pain, moist wheezing, dyspnea and distress.

4. Symptoms of exposure may mimic those of an upper respiratory tract infection, with chest tightness, chills, cough, fever, headache, wheezing and dyspnea, and the symptoms may be delayed as much as 8 hours after exposure.

5. Overexposure may also produce nausea, vomiting, abdominal pain, chest constriction and retrosternal soreness, a choking feeling, productive paroxysmal coughing, bronchospasms, bronchitis, occupational asthma, and sometimes temporal headache, insomnia and paranoid depression. Severe inhalation overexposure can result in pulmonary edema.

6. Dermal contact results in an inflammatory reaction; sensitization is possible. Effects of dermal exposure include itching, redness, swelling, blistering and eczema. When splashed in the eye, 2,6-TDI produces lacrimation, keratitis and conjunctivitis.

7. Chronic exposure can produce a sometimes insidious sensitization of the respiratory tract, with a resultant allergic respiratory reaction including asthma and loss of lung function. Chronic exposure also can result in liver disease, with jaundice, as well as anemia.

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