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| Example of Acute Exposure data from MEDITEXT. |
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CCRIS Documents
DART Documents
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[Effects of the couple exposures to the mixed benzene on gestational processes and pregnancy outcomes]
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A method for evaluation of the potential toxicity to the neonate from exposure to xenobiotics via mother's milk--application to three fragrance materials.
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An in vitro study for the teratogenic potential of xylene and toluene.
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Analytic study to evaluate associations between hazardous waste sites and birth defects--final report.
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Are occupational carcinogens teratogenic?
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Assessment of interactive effects of the aromatic hydrocarbons toluene, xylene and benzene on rat embryonic development in vitro.
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Chronic effects of waterborne or dietary exposure to a herbicide, chlornitrofen (2,4,6-trichlorophenyl-4'-nitrophenyl ether), on reproduction of Polypedilum nubifer (Chironomidae).
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Deficits on a spatial navigation task following prenatal exposure to xylene.
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Developmental and reproductive toxicity of synthetic musks: musk xylene and galaxolide.
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DEVELOPMENTAL TOXICITY OF INHALED ORTHO-, META-, AND PARA-XYLENE IN RATS.
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Effect of the aromatic hydrocarbons toluene, xylene and benzene on rat embryonic development in vitro.
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Effects on reproduction of styrene, toluene and xylene.
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Exposure to aromatic hydrocarbons and complications of pregnancy.
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Final report on the reproductive toxicity of a chemical mixture in CD-1-Swiss mice: volume 2, laboratory supplement.
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Final report on the reproductive toxicity of a complex mixture of groundwater contaminants in Sprague-Dawley rats.
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Health hazard evaluation report HETA 93-1035-2686, U.S. Department of Agriculture, U.S. Forest Service, Washington, DC.
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Induction of birth defects by exposure to solvents: an in vitro study.
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Long-lasting neurobehavioral effects of prenatal exposure to xylene in rats.
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Mixed chemicals (MIX): reproduction and fertility assessment in Swiss (CD-1) mice when administered in the drinking water: final study report, volume I of II.
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Occupational exposures and birth defects: final performance report.
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Reproductive health effects of glycol ether exposure in the semiconductor industry.
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Reproductive risks of glycol ethers and other agents used in semiconductor manufacturing.
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Spontaneous abortions and glycol ethers used in the semiconductor industry: an epidemiologic review.
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Synthetic musk fragrances: bioaccumulation and induction of CYP450 liver enzymes in developing and adult rats.
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Toxicity of three nitro-musks in early lifestages of Xenopus laevis.
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CFR Regulations

Example Content from MEDITEXT for Xylene:
Please note: this is an extract of information from a larger document. Full document and details are available by subscription.
ACUTE EXPOSURE INFORMATION
- Xylene is irritating to the eyes, skin, and mucous membranes. Acute overexposure to xylene has caused renal impairment, evidence of liver function disturbances, temporary confusion, transient memory loss, pulmonary congestion and edema, and focal alveolar hemorrhage.
- Chronic exposure to xylene may cause defatting dermatitis, reversible eye damage, dyspnea, confusion, dizziness, apprehension, memory loss, headache, tremors, weakness, anorexia, nausea, ringing in the ears, irritability, thirst, mild changes in liver function, renal impairment, and anemia. Xylene contaminated with benzene has been associated with blood dyscrasias.
- INHALATION - Inhalation may cause reversible hepatic and renal toxicity. High vapor concentrations can cause CNS excitation followed by narcosis, olfactory changes, respiratory tract irritation, and noncardiogenic pulmonary edema. Severe exposure may result in death due to respiratory arrest and/or ventricular dysrhythmias.
- INGESTION - Xylene ingestion can cause ventricular fibrillation, reversible hepatic and renal toxicity, CNS depression, a burning sensation in the oropharynx and stomach, and vomiting. Pulmonary aspiration can cause pneumonitis and noncardiogenic pulmonary edema.
- DERMAL (LIQUID) - Defatting of the skin with irritation, dryness, erythema, and cracking commonly occur. Blistering may occur, particularly if exposure to concentrated xylene is prolonged and the exposed area of skin is occluded.
- OCULAR - Brief exposure to high vapor concentrations can cause a sensation of irritation. Vacuolar keratopathy has occurred in a few workers with prolonged exposure to high vapor concentrations. Splash accidents have produced transient, superficial injury in most cases. Older literature reports conjunctivitis and occasionally corneal burns following eye contact with liquid xylene.
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